METHOD FOR SIMULATING ISOPROTERENOL-INDUCED CHRONIC HEART FAILURE IN RATS AGED 24 MONTHS Russian patent published in 2024 - IPC G09B23/28 

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to the field of experimentally reproducing human diseases in old age, and can be used for simulating chronic heart failure in laboratory rats aged 24 months. That is ensured by subcutaneous introduction of isoproterenol 10 mg/kg 4 times for 11 days according to the following schedule: 1^st injection on 1^st day of experiment, 2^nd injection on 4^th day of experiment, 3^rd injection on 8^th day of experiment, 4^th injection on 11^th day of experiment. Morphological examination of heart, kidneys, lungs and brain in order to confirm development of chronic heart failure is performed 60 days after the last injection.

EFFECT: invention provides development of persistent morphofunctional changes in myocardial, brain, lung and kidney tissues.

1 cl, 5 dwg, 1 ex