METHOD FOR CREATING TRANSLATIONAL MODEL OF DIABETIC PHENOTYPE OF CHRONIC HEART FAILURE Russian patent published in 2024 - IPC A61K31/133 A61K31/137 A61K31/455 A61P43/00 G09B23/28 

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to experimental cardiology, and can be used to study pathogenetic mechanisms of development, progression of diabetic phenotype of chronic heart failure. Twelve-month male and female rats are fed on a high-calorie diet that includes the main fodder and additionally 50 g/kg of lard and 10 g/kg of butter for 42 days. Diet involves a single intravenous injection of 2.5% nicotinamide in dose of 250 mg/kg. On 21st day of the experiment, streptozotocin is administered in dose of 40 mg/kg. From 28th to 42nd day of the experiment, the daily introduction of 1% mesatone in dose of 0.5 ml/kg is started intramuscularly with underlying physical activity for 15 minutes.

EFFECT: method enables to study new signalling pathways and molecular targets of pathogenesis of chronic heart failure associated with type 2 diabetes mellitus at the preclinical stage, and approbation of new agents and methods of its prevention and treatment.

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