FIELD: biotechnology; medicine.
SUBSTANCE: invention refers to biology and medicine, namely to experimental nephrology and pathophysiology, and can be used for simulating autoimmune mesangial proliferative glomerulonephritis in experiment. For this purpose, a two-month female Wistar rat is injected with 3 ml of an emulsion consisting of 1 ml of 50% suspension of maternal cortical layer antigens and 2 ml of Freund’s complete adjuvant according to the following schedule: once intraperitoneally on 1st, 4th, 7th and 21st days of the experiment.
EFFECT: invention provides 100% reproduction of autoimmune mesangial proliferative glomerulonephritis for a long period of observation, stable clinical course of the disease.
1 cl, 10 dwg, 1 tbl, 1 ex
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