FIELD: chemistry; pharmaceutics.
SUBSTANCE: invention relates to the chemical-pharmaceutical industry, specifically to a method of producing (±)-(12R*,13aR*,13bS*)-2,3,5,6,12,13,13a,13b-octahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij]naphthyridine-12-ol, which is a mixture (±)-isomers of vindeburnol of formula (I), used to treat various neurological pathologies. Method involves reaction of a technical product of formula (II) with 2–20 wt.% solution of potassium hydroxide or sodium hydroxide in ethanol and isopropanol or a mixture thereof, where extraction of mixture of target (±)-isomers of vindeburnol is carried out without extraction.
EFFECT: providing an easy to implement on an industrial scale method of producing vindeburnol from a mixture of vindeburnol with its epimer with high output and optical purity.
4 cl, 1 dwg, 1 tbl, 12 ex
Formula (I)
Formula (II)
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