METHOD FOR DIFFERENTIAL DIAGNOSIS OF CHILD SCHIZOPHRENIA AND CHILD AUTISM BY NUMBER OF COPIES OF GENES CODING RIBOSOMAL RNA IN GENOME OF CHILD WITH MENTAL DISORDERS Russian patent published in 2024 - IPC G01N33/50 C12Q1/6804 

Abstract RU 2816043 C1

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to medical genetics, molecular biology, psychiatry, and paediatrics, and can be used for differential diagnosis of child schizophrenia and autism in children with mental disorder. Copy number of ribosomal DNA (rDNA) in the child’s genome is determined by non-radioactive quantitative hybridisation of DNA recovered from blood cells. If observing more than 536 copies per diploid genome, the child’s schizophrenia is diagnosed. If observing less than 393 copies per diploid genome, the child’s autism is diagnosed.

EFFECT: method provides easy-to-implement and requiring no special high-tech equipment differential diagnosis of schizophrenia and autism in children with mental disorder by determining the number of rDNA copies per diploid gene.

1 cl, 4 dwg, 1 tbl, 2 ex

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RU 2 816 043 C1

Authors

Kostyuk Svetlana Viktorovna

Vejko Natalya Nikolaevna

Ershova Elizaveta Sergeevna

Dolgikh Olga Adolfovna

Kostyuk Svetlana Edmundovna

Salimova Nataliya Agaragimovna

Malinovskaya Elena Mikhajlovna

Porokhovnik Lev Nikolaevich

Nikitina Svetlana Gennadevna

Balakireva Elena Evgenevna

Klyushnik Tatyana Pavlovna

Dates

2024-03-26Published

2023-04-26Filed