METHOD OF DIFFERENTIAL DIAGNOSIS OF CHILDHOOD AUTISM OF MILD SEVERITY, ATYPICAL AUTISM AND SCHIZOPHRENIA IN CHILDREN Russian patent published in 2023 - IPC G01N33/52 G01N33/577 C12Q1/6804 

FIELD: medicine; medical genetics; molecular biology; psychiatry.

SUBSTANCE: invention can be used for differential diagnosis of mild childhood autism, atypical autism and schizophrenia in children. When the level of reactive oxygen species (ROS) and 8-oxodG in peripheral blood mononuclear cells increases by 1.2–1.4 times, the level γ of H2AX by 1.3 times, the concentration of extracellular DNA (cfDNA) by 1.6 times compared to the control, mild childhood autism is diagnosed. When the level of ROS and 8-oxodG in peripheral blood mononuclear cells increases by 2–2.7 times, the level γof H2AX increases by 2–2.5 times, the concentration of cfDNA increases by 3.4 times, the level of 8-oxodG in cfDNA of peripheral blood plasma increases by 2.5–3.3 times compared to the control, the diagnosis of atypical autism is confirmed. When the level of ROS and 8-oxodG in peripheral blood mononuclear cells increases by 2.8–3.5 times, the level γof H2AX increases by 2.6–3.5 times, the concentration of cfDNA increases by 3.5–4 times, the level of 8-oxodG in cfDNA of peripheral blood plasma increases by 3.4–4 times compared to the control, the diagnosis of schizophrenia is confirmed.

EFFECT: method provides the ability to determine the severity of mental disorders in the continuum of autism spectrum disorders and schizophrenia through the use of markers of oxidative stress.

1 cl, 3 dwg, 3 ex