FIELD: veterinary virology and biotechnology.
SUBSTANCE: invention concerns a strain of foot-and-mouth disease virus Aphtae epizooticae genotype O/SEA/Mya-98, family Picornaviridae, genus Aphthovirus, deposited in the Russian State Collection of Exotic Types of Foot and Mouth Disease Virus and other Animal Pathogens (GKShM) of the Federal State Budgetary Institution "ARRIAH" under registration number No. 488 - деп / 23-38 - GKShM FSBI "ARRIAH" strain "O/ARRIAH/Mya-98" of the foot-and-mouth disease virus. The presented strain is reproduced in transplanted cell cultures of Siberian Mountain Ibex Kidney (PSGK-30), Pig Kidney (IB-RS-2), and Newborn Syrian Hamster Kidney (ВНК-21). In a continuous suspension culture of Syrian hamster kidney cells BNK-21/SUSP/ARRIAH over 6.55±0.28 hours of incubation, the concentration of the 146S component of the “O/ARRIAH/Mya-98” foot-and-mouth disease virus strain has an average value of 2.60±0.13 mcg/cm3 (75.16±0.46%), maintaining the original characteristics when passaged in the continuous suspension cell line BNK-21/SUSP/ARRIAH.
EFFECT: presented strain “O/ARRIAH/Mya-98” can be used for production of biological products for the diagnosis and specific prevention of foot-and-mouth disease of the O/SEA/Mya-98 genotype and for monitoring the antigenic activity of foot-and-mouth disease vaccines.
1 cl, 2 dwg, 5 tbl, 7 ex
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