LIPOSOMAL PREPARATIONS Russian patent published in 2024 - IPC A61K9/127 A61K39/395 A61P27/02 

FIELD: medicine; pharmaceutics.

SUBSTANCE: group of inventions relates to pharmaceutics and can be used to treat angiogenic disorders and diseases of the posterior segment of the eye in animals and humans. Disclosed is a local aqueous preparation for treating a disease or condition of the posterior segment of the eye by local delivery to the eye, containing a pharmaceutically effective amount of an anti-angiogenic drug, which is ranibizumab, and a thermodynamically stable, self-forming liposome formed from a polyethylene glycol (PEG)-based lipid, wherein the weight percent of the lipid is less than 20 wt.%. Also disclosed is the use of said local preparation for treating a VEGF-mediated disease or condition in a patient in need of such treatment, where the disease is selected from age-related macular degeneration, diabetic retinopathy, diabetic macular oedema, and corneal neovascularisation.

EFFECT: invention provides a preparation which can be effectively introduced locally into the involved eye, and this introduction is more effective than the introduction of the intravitreal preparation.

10 cl, 7 dwg, 1 tbl, 4 ex