C26-LINKED ANALOGUES OF RAPAMYCIN AS MTOR INHIBITORS Russian patent published in 2024 - IPC C07D498/18 C07D519/00 A61K31/436 A61P25/00 A61P35/00 A61P37/00 

Abstract RU 2826559 C2

FIELD: chemistry.

SUBSTANCE: invention relates to compounds of formula Ia, as well as to a pharmaceutical composition for inhibiting mTOR activity and methods of treating diseases or disorders mediated by mTOR.

EFFECT: novel compounds having activity on mTOR, which can be used in the treatment of diseases mediated by said activity, such as cancer or an immune-mediated disease, are obtained.

62 cl, 70 ex, 30 tbl

(Iа)

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RU 2 826 559 C2

Authors

Semko, Christopher Michael

Wang, Gang

Burnett, G. Leslie

Aggen, James Bradley

Kiss, Gert

Cregg, James Joseph

Gliedt, Micah James Evans

Pitzen, Jennifer

Lee, Julie Chu-Li

Won, Walter

Thottumkara, Arun P.

Gill, Adrian Liam

Dates

2024-09-12Published

2019-04-29Filed