METHOD OF PRODUCING 4-ARYL-SUBSTITUTED 7-HYDROXY-6'-PHENYL-5',6'-DIHYDRO-1'H-SPIRO[CHROMAN-2,4'-PYRIMIDINE]-2'(3'H)-ONES Russian patent published in 2024 - IPC C07D491/107 

FIELD: chemistry.

SUBSTANCE: invention relates to organic synthesis and pharmaceutics, specifically to a method of producing 4-aryl-substituted 7-hydroxy-6'-phenyl-5',6'-dihydro-1'H-spiro[chroman-2,4'-pyrimidine]-2'(3'H)-ones of structural formula (1), which can be used as precursors for synthesis of biologically active substances and medicinal preparations. Method of producing compounds of general formula (1), where R₁=H, or Cl, or Me, or MeO, R₂=H or Me, is characterized by that the synthesis reagents used are 6-styryl-substituted 4-phenyl-3,4-dihydropyrimidin-2(1H)-ones and resorcins, such as benzene-1,3-diol or 2-methylbenzene-1,3-diol, in molar ratio of 1:2, which react in a solution of chloroform and water in the presence of n-toluenesulphonic acid at temperature of 30–40 °C for 1–3 hours. Obtained reaction mass is cooled, the precipitate is filtered, washed with water, recrystallised from ethyl acetate and dried in air.

EFFECT: providing a method for synthesis of new target spiro[chroman-2,4'-pyrimidine]-2'(3'H)-ones.

1 cl, 8 ex

formula (1)