FIELD: chemistry.
SUBSTANCE: invention relates to a method of producing 6-aryl-substituted 5-acetyl-4-(2,4-dihydroxyphenyl)-4-methylhexahydropyrimidin-2-ones (thiones) of structural formula
,
where R=C6H5, or 4-ClC6H4, or 4-MeC6H4, or 4-MeOC6H4, X=O or S, which involves reaction of 4-aryl-substituted 5-acetyl-6-methyldihydropyrimidin-2-ones (thiones) and benzene-1,3-diol.
EFFECT: method of producing 6-aryl-substituted 5-acetyl-4-(2,4-dihydroxyphenyl)-4-methyl-hexahydropyrimidin-2-ones (thions) enables to obtain new substituted hexahydropyrimidin-2-ones (thiones), which have not been previously described, which can be used as precursors for synthesis of biologically active substances and medicinal preparations.
1 cl, 8 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD FOR PRODUCING SUBSTITUTED (4R*,5S*,6R*)-2-THIOHEXAHYDROPYRIMIDINE-5-CARBOHYDRAZIDES | 2021 |
|
RU2776954C1 |
| METHOD OF PRODUCING 4-ARYL-SUBSTITUTED 8-HYDROXY-5,10A-DIMETHYL-1,3,4,10A-TETRAHYDRO-2H-CHROMENO[2,3-D]PYRIMIDIN-2-ONES(THIONS) | 2023 |
|
RU2821110C1 |
| CHIRAL S-MONO-PERPENYL-CYSTEINES | 2018 |
|
RU2689381C1 |
| METHOD FOR THE PREPARATION OF SUBSTITUTED 8-HYDROXY-1,2,3,4,4A,10B-HEXAHYDRO-2H-CHROMENO[4,3-D]PYRIMIDINE-2,5(1H)-DIONES | 2022 |
|
RU2785713C1 |
| METHOD FOR PREPARING SUBSTITUTED O-ALKYLATED HEXAHYDRO-2H-CHROMENO[4,3-D]PYRIMIDINE-2,5(1H)-DIONES | 2022 |
|
RU2796532C1 |
| 2-AMINO-SUBSTITUTED 6-METHOXY-4-TRIFLUOROMETHYL-9H-PYRIMIDO[4,5B]INDOLES, METHOD FOR THEIR PRODUCTION, APPLICATION AND PREDIMINARIES | 2016 |
|
RU2625316C1 |
| METHOD OF OBTAINING AMIDRAZONES OF 4-R-1,2,5-OXADIAZOLE-3-CARBOXYLIC ACID | 2014 |
|
RU2557659C1 |
| SECONDARY MANNOSIS FOR BACTERIAL INFECTIONS TREATMENT | 2013 |
|
RU2667060C2 |
| CONDENSED AMINOHYDROTHIAZINE DERIVATIVE | 2009 |
|
RU2476431C2 |
| β-LACTAMS, METHOD FOR PREPARING INDICATED COMPOUNDS AND SERUM HYPOCHOLESTEROLEMIC AGENTS CONTAINING SUCH COMPOUNDS | 2002 |
|
RU2301799C2 |
