HETEROCYCLIC COMPOUNDS USED IN TREATING DISEASE Russian patent published in 2024 - IPC C07D231/38 C07D401/04 C07D401/14 A61K31/415 A61P1/16 A61P3/00 

FIELD: chemistry.

SUBSTANCE: group of inventions relates to organic chemistry and includes a compound of formula I, a pharmaceutically acceptable salt thereof, a pharmaceutical composition and use thereof, as well as individual compounds specified in the claim. In formula IR^A is tetrazolyl, -C(=O)NH₂, -C(=O)NHR^B, -CONHCN, -C(=O)NHSO₂R^B or -C(=O)NHCH₂CH₂SO₃H; R^B represents C₁-C₄ alkyl; L¹ is ; in ring R^H is -H, halogen or C₁-C₄ alkyl; in ring A¹ is CH or N and R^H is absent; ring A is characterized by the structure ; where R^C is -Cl; R^D is -N(R^F)-C(=O)XCH(R^G)-CY (Formula II), where X is O and CY is unsubstituted phenyl, where R^H is absent, or substituted phenyl, where R^H is -F or -Cl in Formula II

R^F is -H, or C₁-C₄ alkyl, or C₃-C₆ cycloalkyl; R^G is -CH₃ in R-configuration.

EFFECT: compounds which inhibit the physiological activity of lysophosphatidic acid (LPA) and are used as agents for treating or preventing LPA-dependent diseases.

30 cl, 2 tbl, 29 ex