FIELD: biotechnology.
SUBSTANCE: disclosed is use of an antibody which binds to PD1 and inhibits it, when producing a drug for treating a subject with cancer. Subject has a tumour with a total load of passenger gene mutations exceeding the background mutation load of the tumour. Selection of a patient with cancer for immunotherapy involves determining a total load of passenger tumour gene mutations in a patient with cancer, obtaining a background distribution for the mutation load of the tumour, normalizing the total load of passenger gene mutations relative to the baseline distribution and referring the patient with cancer to the category of responders for immunotherapy if the total load of passenger gene mutations exceeds the average value of the baseline distribution.
EFFECT: invention provides effective selection of patients-responders for cancer immunotherapy.
43 cl, 14 dwg, 4 tbl, 4 ex
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Authors
Dates
2024-05-21—Published
2018-09-19—Filed