METHODS OF USING BISPECIFIC ANTIGEN-BINDING CONSTRUCT TARGETING HER2 FOR TREATING BILE DUCT CANCER Russian patent published in 2024 - IPC A61K39/395 A61K47/50 A61P35/00 A61P1/16 C07K16/46 C07K16/30 C12N15/13 

FIELD: medicine.

SUBSTANCE: group of inventions relates to oncology and hepatology, includes a method of treating a subject with oncological disease of the biliary system (ODBS). Effective amount of a bispecific antigen-binding construct to HER2 or an antibody-drug conjugate (ADC) is administered to a subject. Bispecific antigen-binding construct to HER2 contains a heavy chain H1, a heavy chain H2 and a light chain L1, wherein: a) heavy chain H1 contains sequences CDR SEQ ID NO: 39, SEQ ID NO: 40 and SEQ ID NO: 41; b) heavy chain H2 contains sequences CDR SEQ ID NO: 67, SEQ ID NO: 68, SEQ ID NO: 69, SEQ ID NO: 70, SEQ ID NO: 71 and SEQ ID NO: 72; and c) light chain L1 contains sequences CDR SEQ ID NO: 27, SEQ ID NO: 28 and SEQ ID NO: 29. Drug in ADC contains auristatin or its analogue. Group of the declared inventions also includes the use of a bispecific antigen-binding construct to HER2 or ADC when preparing a medicinal agent for treating ODBS.

EFFECT: method provides the possibility of treating ODBS in a patient by using a bispecific antigen-binding construct to HER2 or ADC containing the declared nucleotide sequences.

34 cl, 2 dwg, 12 tbl, 4 ex