LIGAND COMPOUNDS, CONJUGATES AND USE THEREOF Russian patent published in 2024 - IPC C07H13/06 C07H15/26 C07H21/00 C12N15/113 A61K31/7028 A61K31/7115 A61K31/713 A61K47/54 A61K48/00 A61P1/16 

FIELD: medicine; pharmaceuticals.

SUBSTANCE: invention relates to a compound of general formula (I) or a pharmaceutically acceptable salt thereof, where each R^X independently represents a group of formula (A1); each R¹ independently represents a group of formula (Bl-a); each R^B independently represents -NR^E R^F; each R^C independently represents -C(=O)C_1-6 alkyl; each R^E independently represents C(=O)C_1-6 alkyl; each R^F is independently H; each R² is independently selected from a group consisting of: -C(R⁶)₂-; *-NR⁷C(=O)-; where * represents a point of attachment to the structure presented in the claims; R³ is selected from a group given in the claim; -L³ is –C(R⁶)₂-; R⁴ is selected from a group consisting of: -C(R⁶)₂-; *-NR⁷C(=O)-; - R⁵ is selected from the group given in the claim, where Pg is C_6-10 aryl substituted with 1–5 substituents, each of which is independently selected from the group given in the claim, where Pg² is selected from the group consisting of 4-monomethoxytrityl (MMTR); 4,4-dimethoxytrityl (DMTR); and triphenylmethyl (trityl); each R⁶ is independently selected from a group consisting of: H; each R⁷ is independently selected from a group consisting of: H; each of a and b is an independently selected integer from 1 to 10; each of c and d is an independently selected integer from 1 to 10. Invention also relates to a conjugated compound, use of the conjugated compound, a method for detecting or localizing RNA in the liver, a pharmaceutical composition and use of the pharmaceutical composition.

EFFECT: novel compounds which contain one or more asialoglycoprotein receptor (ASGPR) ligand fragments and which can additionally contain an oligonucleotide used for targeted delivery of oligonucleotides to liver cells.

16 cl, 5 tbl, 18 ex