FIELD: biotechnology.
SUBSTANCE: invention relates to the field of biotechnology. Described is a group of inventions comprising a compound for inhibiting complement factor B (CFB) expression (embodiments), a pharmaceutical composition for treating a disease associated with deregulation of an alternative complement pathway in a subject, a method of treating a disease associated with deregulation of an alternative complement pathway in a subject, use of said compound or composition for treating a disease associated with dysregulation of an alternative complement path, using said compound or composition when preparing a drug for treating a disease associated with deregulation of an alternative complement pathway. In one embodiment, the compound contains a modified oligonucleotide and a conjugate group.
EFFECT: invention extends the range of agents for inhibiting complement factor B (CFB) expression.
42 cl, 232 tbl, 135 ex
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Authors
Dates
2019-09-30—Published
2015-05-01—Filed