FIELD: biotechnology.
SUBSTANCE: invention relates to biotechnology, immunology and biomedicine, in particular to an improved synthetic T-cell receptor and an antigen receptor (STAR) targeting CD19 and CD20, a T cell comprising a synthetic T cell receptor and an antigen receptor and use thereof.
EFFECT: invention provides obtaining improved TCR and corresponding TCR-T therapy.
43 cl, 45 dwg, 28 tbl, 2 ex
| Title | Year | Author | Number |
|---|---|---|---|
| CHIMERIC ANTIGEN RECEPTOR | 2016 |
|
RU2752880C2 |
| CHIMERIC ANTIGENE RECEPTOR | 2019 |
|
RU2810092C2 |
| T-CELL RECEPTORS | 2017 |
|
RU2775623C2 |
| CHIMERIC ANTIGEN RECEPTOR (CAR) WITH ANTIGEN-BINDING DOMAINS TO THE T-CELL RECEPTOR β- CONSTANT REGION | 2015 |
|
RU2744046C2 |
| T-CELL RECEPTORS | 2018 |
|
RU2762255C2 |
| HLA-NON-RESTRICTED T-CELL RECEPTORS AND THEIR USE | 2019 |
|
RU2812917C2 |
| T-CELL RECEPTORS SPECIFIC RELATIVELY TO COMPLEX OF TUMOR ANTIGEN NY-ESO-1/HLA-A*02 | 2016 |
|
RU2775394C2 |
| CHIMERIC ANTIBODY/T-CELL RECEPTOR STRUCTURES AND THEIR APPLICATIONS | 2016 |
|
RU2767209C2 |
| T-CELL RECEPTOR CONSTRUCTS AND THEIR USE | 2019 |
|
RU2785954C2 |
| BISPECIFIC ANTIBODIES SPECIFIC RELATIVELY TO COSTIMULATORY TNF-RECEPTOR | 2016 |
|
RU2761115C1 |
