FIELD: biotechnology.
SUBSTANCE: invention relates to the field of biotechnology, specifically to producing a polypeptide forming a chimeric antigen receptor (hereinafter – CAR) containing antigen-binding domain, super-spiral spacer domain, transmembrane domain, and endo-domain; it can be used in medicine.
EFFECT: multimeric CAR formed by combining a set of polypeptides forming CAR by association of their super-spiral domains can be used for the effective immunotherapy of cancer.
37 cl, 16 dwg, 5 tbl, 7 ex
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