NOVEL 2-ARYLTHIAZOLE DERIVATIVE OR SALT THEREOF, METHOD FOR PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION CONTAINING THEREOF Russian patent published in 2024 - IPC C07D277/56 C07D417/12 A61K31/426 A61K31/454 A61K31/4545 A61K31/5377 A61K31/551 A61P1/16 A61P3/10 A61P25/16 A61P25/28 

FIELD: chemistry.

SUBSTANCE: invention relates to 2-arylthiazole derivative and salts thereof, represented by general formula 1, where R₁ is hydrogen, C₁~C₄-alkyl group or C₁~C₄-alkyl group substituted with mono- or di-C₁~C₅-alkylamino; R₂ is C₁~C₄-alkyl group; A is a group selected from a group consisting of the following groups of formulas: 1a, 1b, 1c and 1d; in formulas 1a, 1b, 1c and 1d * denotes a site attached to a compound of formula 1; n is 1, 2 or 3; R₃ and R₄, independently of each other, are hydrogen or C₁~C₄-alkyl; or R₃ and R₄ are bonded to each other, to the nitrogen atom to which they are bonded, to form piperidine, morpholine or pyrrolidine, where piperidine, morpholine or pyrrolidine is optionally substituted with C₁~C₄-alkyl; R₅ and R₆ are C₁~C₄-alkyl; or R₅ and R₆ form a ring to form cyclopentane, cyclohexane or tetrahydropyran; Cy is a nitrogen-containing heterocyclic group selected from the group consisting of homopiperazinyl, piperidinyl, morpholinyl and pyrrolidinyl, wherein the nitrogen-containing heterocyclic group is optionally substituted with C₁~C₄-alkyl or benzyl. Invention also relates to a method of producing a compound of formula 1 and a pharmaceutical composition containing a compound of formula 1.

EFFECT: derivatives of 2-arylthiazole used to treat autophagy-related diseases.

12 cl, 10 tbl, 36 ex, 5 dwg