FIELD: chemistry.
SUBSTANCE: group of inventions relates to organic chemistry and includes a compound of formula (I), a tautomer thereof or a pharmaceutically acceptable salt of said compound or tautomer, a pharmaceutical composition based thereon and intermediate compounds of formulas (II) and (III). In formula (I), R1 is selected from (C1-C4)alkyl, (C1-C4) fluoroalkyl and CH2OCH3; each of R2, R3 and R4 is independently selected from hydrogen and fluorine; R5 is selected from hydrogen, fluorine, (C1-C4)alkoxy and cyclopropoxy. In formulas (II), (III) R1, R2, R3, R4 and R5 are as defined for formula (I), PG is a protective group selected from tert-butyloxycarbonyl, benzyloxycarbonyl, 9-fluorenylmethyloxycarbonyl or trichloroethoxycarbonyl.
EFFECT: substituted cyanopyrrolidines of formula (I), having USP30 inhibitory activity.
20 cl, 5 ex
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