FIELD: biotechnology.
SUBSTANCE: described is a recombinant adeno-associated virus (rAAV) cell line containing a plurality of cells in which expression KCNN2, RGMA, ATP5EP2, LINC00319, CYP3A7, ABCA10, NOG, SPANXN3, PGA5, MYRIP and/or NALCN-AS1 is reduced compared to control parent cells. Invention also describes a method of producing an rAAV producer cell line and a method of producing rAAV.
EFFECT: obtaining improved rAAV titres for use in gene therapy by providing rAAV producer and/or packer cell lines in which one or more genes and/or proteins have been modified.
44 cl, 30 dwg, 5 tbl, 8 ex
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