COMPOUNDS AND METHODS FOR TREATING FUNGAL INFECTIONS Russian patent published in 2024 - IPC A61K31/85 A61K31/422 A61K31/675 A61P31/10 

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to a method of treating a fungal infection. Method of treating a fungal infection in a subject, comprising administering to a subject with a fungal infection a therapeutically effective amount of compound 1:

,

or a pharmaceutically acceptable salt, solvate or hydrate thereof, wherein the fungal infection in the subject is caused by Candida spp., wherein a therapeutically effective amount of compound 1 provides 24-hour area under the concentration-time curve (AUC_0-24) at a steady state in a subject taking at least 150 mcg×pts./ml of compound 1A:

;

where the subject has contraindications to standard antifungal therapy due to chronic kidney disease (CKD); wherein administering compound 1 or a pharmaceutically acceptable salt, solvate or hydrate thereof to a subject comprises a therapeutic regimen consisting of daily administration of compound 1 or a pharmaceutically acceptable salt, solvate or hydrate thereof for at least 1–4 weeks; where the therapeutic regimen comprises a loading dose of compound 1 or a pharmaceutically acceptable salt, solvate or hydrate thereof and a maintenance dose of compound 1 or a pharmaceutically acceptable salt, solvate or hydrate thereof; where the loading dose of compound 1 or its pharmaceutically acceptable salt, solvate or hydrate is 2000 mg; and wherein the maintenance dose comprises a single daily administration of 600 mg to 1500 mg of compound 1 or a pharmaceutically acceptable salt, solvate or hydrate thereof.

EFFECT: said invention enables treating a fungal infection caused by Candida species in subjects with chronic kidney disease.

37 cl, 3 tbl, 3 ex