FIELD: pharmaceutical industry.
SUBSTANCE: invention relates to a natamycin derivative modified at the carboxyl group by an amine residue, the structure of which contains an additional main group corresponding to the following formula:
,
as well as its pharmaceutically acceptable salts and solvates. In the given formula: R is independently an amino group; an alkylamino group containing from 1 to 6 carbon atoms optionally substituted with phenyl, halophenyl or hydroxy; pyridin-2-yl, pyridin-3-yl, pyridin-4-yl, optionally quaternized with an alkyl group containing from 1 to 14 carbon atoms; n = 1-4. Also a method of producing a natamycin derivative and a method of treating systemic fungal infections caused by strains of Candida spp are proposed.
EFFECT: invention makes it possible to create more effective antifungal agents based on new semi-synthetic natamycin amides.
5 cl, 5 tbl, 11 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD FOR OBTAINING ANTIFUNGAL SEMISYNTHETIC POLYENE ANTIBIOTIC | 2020 |
|
RU2751333C1 |
| ANTIFUNGAL SEMI-SYNTHETIC POLYENE ANTIBIOTIC, WATER-SOLUBLE SALTS THEREOF AND PHARMACEUTICAL COMPOSITIONS BASED THEREON | 2018 |
|
RU2688658C1 |
| PEPTIDE COMPOUND CAPABLE OF BINDING WITH PSMA, METHOD FOR PRODUCTION AND USE THEREOF | 2021 |
|
RU2823164C2 |
| CYTOTOXIC LINEAR HETEROCYCLIC DERIVATIVES OF ANTHRACENEDIONE HAVING IN SIDE CHAIN CYCLIC DIAMINES, ACTIVE TOWARDS TUMOUR CELLS WITH MULTIDRUG RESISTANCE | 2009 |
|
RU2412166C1 |
| SPIRO[2,3]HEXANE AMINO ACIDS - CONFORMATIONAL-HARD ANALOGUES OF (-AMINOBUTYRIC ACID - AND METHODS FOR THEIR OBTAINING | 2016 |
|
RU2629357C1 |
| OXAZOLIDINONES BASED ON PYRIDOXINE DERIVATIVES, HAVING ANTIBACTERIAL ACTIVITY | 2024 |
|
RU2836570C1 |
| 2-SUBSTITUTED-1,2,4,5-TETRAHYDRO-3H-PYRROLO[1,2-a][1,4]DIAZEPIN-3-ONES | 2011 |
|
RU2472795C1 |
| DERIVATIVES OF 1,4-DIOXIDE OF QUINOXALINE-2-CARBONITRILE INHIBITING TUMOUR CELLS GROWTH | 2016 |
|
RU2640304C1 |
| METHOD FOR SYNTHESIS OF BENZO[7,8]AZONINO[5,4-b]INDOLE, 7,9-ETHENO-AZECINO [5,4-b]INDOLE AND 7,9-ETHANO-AZECINO[5,4-b]INDOLE DERIVATIVES | 2009 |
|
RU2397984C1 |
| LIGANDS, TROPIC TO PROSTATIC SPECIFIC MEMBRANE ANTIGEN AND USE THEREOF FOR OBTAINING DOUBLE CONJUGATES WITH THERAPEUTIC AGENTS BASED THEREON FOR COMBINED THERAPY OF PSMA EXPRESSING TUMOURS | 2023 |
|
RU2841078C1 |
