FIELD: chemistry.
SUBSTANCE: invention relates to a method of producing compound I (ivosidenib) used in treating patients with haematological malignancies. Disclosed method involves extraction of crystalline ethanol solvate of compound IIa and conversion of ethanol solvate of compound IIa to compound I or its solvate. Invention also relates to a crystalline ethanol solvate of compound IIa and a method for production thereof.
EFFECT: disclosed method enables efficient synthesis of ivosidenib using diastereomerically pure crystalline ethanol solvate of compound IIa.
29 cl, 2 dwg, 4 tbl, 46 ex
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