FIELD: chemistry.
SUBSTANCE: invention relates to crystalline monohydrate of elobixibat, which can be used in preparations for the treatment or prevention of diseases associated with inhibition of the ileal bile acid transporter (IBAT). Disclosed crystalline monohydrate of elobixibat is a crystalline modification IV of elobixibat, having an X-ray powder diffractogram (XPD) obtained using CuKα1-radiation, with peaks at the following values of the angle (2θ): 6.3±0.2 and 19.4±0.2. Invention also relates to crystalline modification I of elobixibat, a process for the production of crystalline modification IV of elobixibat, crystalline modifications EtOH-1, MeOH-1, 1-PrOH-1 and 2-PrOH-1 of elobixibat and their use in production of crystalline modification IV of elobixibat, a pharmaceutical composition.
EFFECT: crystalline modification is disclosed.
22 cl, 1 tbl, 21 dwg, 17 ex
| Title | Year | Author | Number |
|---|---|---|---|
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