METHOD OF TREATING PULMONARY AND BRONCHIAL TUBERCULOSIS IN VARIOUS X-RAY SYNDROMES Russian patent published in 2024 - IPC A61K31/00 A61K31/137 A61K31/58 A61K9/08 A61K9/12 A61P11/00 A61P31/00 

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to phthisiology, and concerns a method of treating pulmonary and bronchial tuberculosis taking into account X-ray syndromes. Preliminary, complex diagnostics is carried out in order to verify the tuberculosis process of the respiratory organs, including the examination of sputum by a molecular genetic method, by a luminescent microscopy method and inoculation on liquid and solid nutrient media to identify the pathogen, determining the drug resistance spectrum of the agent, examining the respiratory function and detecting X-ray syndrome using MSCT of the thoracic organs. If observing X-ray syndromes in the form of cavities, confluent foci of infiltration and tuberculosis, lymphadenopathy of intrathoracic lymph node and atelectasis of pulmonary tissue, bronchoscopy is performed to confirm tuberculosis of bronchi and to collect diagnostic material, and biochemical and coagulogic studies are performed. In the presence of an X-ray syndrome in the form of a disintegration cavity, an anti-tuberculosis therapy is prescribed based on the data of drug resistance of Koch's bacillus with preferential intravenous and intramuscular introduction of chemopreparations in MDR/XDR TB for period of 18–24 months, at drug susceptibility of Koch's bacillus for at least 6 months, and inhalation therapy in the amount of mucolytic expectorant, antiseptic and inhaled glucocorticosteroids. In the presence of an X-ray syndrome in the form of an infiltration, an anti-tuberculosis therapy is prescribed taking into account the data of the drug resistance of Koch's bacillus with the parenteral introduction of chemopreparations in MDR/XDR TB for period of 18–24 months, at drug susceptibility of Koch's bacillus for at least 6 months, include lymphotropic therapy to increase bioavailability of chemopreparations daily, prescribed inhalation therapy in amount of mucolytic expectorant in presence of destruction cavity less than 4 cm, antiseptic and inhaled glucocorticosteroids. In the presence of X-ray syndrome in the form of intrathoracic lymphadenopathy, atelectasis of pulmonary tissue, anti-tuberculosis therapy with parenteral administration of chemopreparations is prescribed with MDR/XDR TB for period of 18–24 months, drug susceptibility of Koch's bacillus for at least 6 months, a lymphotropic therapy is daily prescribed in the absence of contraindications, as well as systemic oral glucocorticosteroids for period of 1.5 months with subsequent withdrawal of the preparation, inhalation therapy in the amount of an antiseptic, inhaled glucocorticosteroids.

EFFECT: invention provides an increase in the effectiveness of the integrated treatment of patients with respiratory tuberculosis in the presence of an X-ray syndrome in the patients, achieved in a method involving a comprehensive diagnosis and in the presence of an X-ray syndrome or in the form of a decay cavity, or in the form of infiltration, or in the form of intrathoracic lymphadenopathy, an anti-tuberculosis therapy with parenteral administration of chemopreparations, lymphotropic therapy, as well as systemic oral glucocorticosteroids and inhalation therapy taking into account a specific syndrome.

1 cl, 9 dwg, 3 ex