DIAZABENZOFLUORANTHRENE COMPOUNDS Russian patent published in 2019 - IPC C07D461/00 C07D519/00 A61K31/4745 A61P9/10 A61P25/08 

Abstract RU 2697513 C2

FIELD: medicine; pharmaceuticals.

SUBSTANCE: invention relates to a compound of formula (I), to its pharmaceutically acceptable salts or tautomers, where R1 is independently selected from H or optionally substituted R01 S(=O)2NH2; R3 is independently selected from C1-10alkyl; R2 selected from , , , , , , , , , , or ; where from zero to two T21-23 are N, and the rest are C(Rt); D21 is selected from -C(Rd1)(Rd2)-, -N(Rd4)-, -O-, -S- or -C(=O)-; T24 is selected from N or C(Rt); each of D22-24 is independently selected from -C(Rd1)(Rd2)-, -O-, -S- or -C(=O)-; up to two T25-29 are N, and the rest are C (Rt); optionally any two of Rt and Rd1-d4 are bonded together with common atom or group of atoms to form one 5-6-member ring; each of Rt, Rd1 and Rd2 is independently selected from H, CN, NH2, C(=O)NH2, C(=O)N(CH3)2; or Rt is independently selected from a group consisting of optionally substituted R01 C1-10alkyl, C1-10heteroalkyl, tetrahydropyranyl, tetrahydropyridinyl, morpholinyl, pyridinyl, , , , CF3, CH2CF3, CH2CHF2 or phenyl; R01 is selected from OH or R02; R02 is selected from C1-10alkyl, C1-10heteroalkyl, C3-10cycloalkyl, heterocyclic C6alkyl, which contains carbon atoms and 1 heteroatom, selected from O; wherein "hetero-" denotes a heteroatom or heteroatom-containing group selected from a group consisting of -C(=O)N(Rd3)- or -C(=O)O-; each of Rd3-d4 is independently selected from H or CH3; R02 optionally substituted with R001; R001 is selected from F, Cl, Br, I, OH or methyl, wherein the number of each of R01, R001, heteroatoms or heteroatom-containing groups independently is selected from 0, 1, 2, 3 or 4.

EFFECT: obtaining novel compounds which can be used in medicine in preparing a medicinal preparation for treating apoplexy of brain or epilepsy by inhibiting PDE1 activity.

10 cl, 2 tbl, 84 ex

Similar patents RU2697513C2

Title Year Author Number
SALTS AND CRYSTALLINE FORMS OF DIAZABENZOFLUORANTHENE COMPOUNDS 2017
  • Lu, Qingqing
  • Shi, Shenyi
  • Bai, Tiezhong
  • Yuan, Shujie
  • Li, Zhengwu
  • Hu, Qiaofen
  • Cao, Yijie
  • Gao, Jing
  • Ding, Hui
  • Li, Jinhua
  • Xu, Guanghai
  • Wang, Zheng
  • Jin, Xin
RU2762189C2
TRICYCLIC OXAZOLIDINONE ANTIBIOTIC COMPOUNDS 2009
  • Kristian Khubshverlen
  • Daniel' Ritts
  • Georg Rjuehdi
  • Zhan-Filipp Sjurive
  • Kornelia Tsumbrunn-Aklen
RU2530884C2
PYRAZINE COMPOUNDS AND THEIR USE 2019
  • Qi Changhe
  • Tsui Honchung
  • Zeng Qingbei
  • Yang Zhenfan
  • Zhang Xiaolin
RU2809631C2
THIENODIAZEPINE DERIVATIVES AND THEIR USE 2018
  • Shen, Chunli
  • U, Chende
  • Lyu, Yun
  • Gun, Chzhen
  • Li, Tszyan
  • Chen, Shukhuej
RU2795005C2
FGFR INHIBITOR AND ITS MEDICAL USE 2018
  • Wang, Yikai
  • Zhang, Yang
  • Chen, Zhengxia
  • Chen, Linlin
  • Feng, Tao
  • Huang, Rongxin
  • Li, Qiu
  • Li, Deyao
  • Sun, Jikui
  • Xu, Yangyang
  • Li, Jie
  • Li, Jian
  • Chen, Shuhui
RU2771311C2
CDK4/6 INHIBITOR 2017
  • Xu Zhaobing
  • Hu Lihong
  • Ding Charles Z.
  • Chen Shuhui
RU2747311C2
ANALOGUES OF 4H-PYRAZOLO[1,5-A]BENZIMIDAZOLE COMPOUNDS AS PARP INHIBITORS 2015
  • Van Syuekhaj
  • Din Chzhaochzhun
  • Syuj Yun
  • Chen Shukhuej
  • Li Le
  • Li Gan
  • Tu Zhunkhua
  • Van Tsajlin
  • Yue Yan
  • Chzhan Chzhibo
  • Chen Khajlyan
  • Sun Ventsze
  • Khuan Lu
RU2672722C2
METHOD FOR IDENTIFICATION OF ANTI-TUMOR TARGET ENZYMES 2002
  • Isitsuka Khideo
  • Okabe Khisafumi
  • Simma Nobuo
  • Tsukuda Takuo
  • Umeda Isao
RU2319482C2
SUBSTITUTED INDOLES, ANTIVIRAL ACTIVE COMPONENT, SYNTHESIS AND APPLICATION METHOD 2010
  • Ivashchenko Aleksandr Vasil'Evich
  • Bychko Vadim Vasil'Evich
  • Mit'Kin Oleg Dmitrievich
RU2436786C1
PYRIDONE AND AZA-PYRIDONE COMPOUNDS AND METHODS OF USE 2011
  • Barbosa Antonio Dzh. M.
  • Blomgren Piter A.
  • Kurri Kevin S.
  • Krishnamurti Ravi
  • Kropf Dzheffri E.
  • Li Seng Kh.
  • Mitchell Skott A.
  • Ortvajn Deniel
  • Shmitt Aaron S.
  • Van Syaotszin
  • Syuj Tszyantszyun
  • Yang Vendi
  • Chzhan Khunlu
  • Chzhao Chzhundun
  • Zhichkin Pavel E.
RU2617405C2

RU 2 697 513 C2

Authors

Yuan Shujie

Yang Xinchun

Zhao Jinlong

Zhang Daoxu

Sun Mingda

Liu Jiaji

Wei Tao

Zhao Huanan

Luo Yunfu

Yang Chundao

Dates

2019-08-15Published

2016-02-02Filed