DIAZABENZOFLUORANTHRENE COMPOUNDS Russian patent published in 2019 - IPC C07D461/00 C07D519/00 A61K31/4745 A61P9/10 A61P25/08 

FIELD: medicine; pharmaceuticals.

SUBSTANCE: invention relates to a compound of formula (I), to its pharmaceutically acceptable salts or tautomers, where R₁ is independently selected from H or optionally substituted R₀₁ S(=O)₂NH₂; R₃ is independently selected from C_1-10alkyl; R₂ selected from , , , , , , , , , , or ; where from zero to two T_21-23 are N, and the rest are C(R_t); D₂₁ is selected from -C(R_d1)(R_d2)-, -N(R_d4)-, -O-, -S- or -C(=O)-; T₂₄ is selected from N or C(R_t); each of D_22-24 is independently selected from -C(R_d1)(R_d2)-, -O-, -S- or -C(=O)-; up to two T_25-29 are N, and the rest are C (R_t); optionally any two of R_t and R_d1-d4 are bonded together with common atom or group of atoms to form one 5-6-member ring; each of R_t, R_d1 and R_d2 is independently selected from H, CN, NH₂, C(=O)NH_2, C(=O)N(CH₃)₂; or R_t is independently selected from a group consisting of optionally substituted R₀₁ C_1-10alkyl, C_1-10heteroalkyl, tetrahydropyranyl, tetrahydropyridinyl, morpholinyl, pyridinyl, , , , CF₃, CH₂CF₃, CH₂CHF₂ or phenyl; R₀₁ is selected from OH or R₀₂; R₀₂ is selected from C_1-10alkyl, C_1-10heteroalkyl, C_3-10cycloalkyl, heterocyclic C₆alkyl, which contains carbon atoms and 1 heteroatom, selected from O; wherein "hetero-" denotes a heteroatom or heteroatom-containing group selected from a group consisting of -C(=O)N(R_d3)- or -C(=O)O-; each of R_d3-d4 is independently selected from H or CH₃; R₀₂ optionally substituted with R₀₀₁; R₀₀₁ is selected from F, Cl, Br, I, OH or methyl, wherein the number of each of R₀₁, R₀₀₁, heteroatoms or heteroatom-containing groups independently is selected from 0, 1, 2, 3 or 4.

EFFECT: obtaining novel compounds which can be used in medicine in preparing a medicinal preparation for treating apoplexy of brain or epilepsy by inhibiting PDE1 activity.

10 cl, 2 tbl, 84 ex