FIELD: medicine; pharmaceutics.
SUBSTANCE: present invention relates to pharmaceutical chemistry, specifically to a compound of general formula (I), or a pharmaceutically acceptable salt thereof, where X is C(O) or (CH2)n; n is 0 or 1; R1 is hydrogen, C1-C8 alkyl group or -NR4R5, where R4, R5 are selected from hydrogen, C1-C8 alkyl group or C3-C8 cycloalkyl group; R2 is F; R3 is hydrogen or C1-C8 alkyl group. Invention also relates to a method of producing said compound, as well as a pharmaceutical composition and use thereof.
EFFECT: obtaining alternative compounds, which are inhibitors of double targeted action on CDK6/DYRK2, which can be used in medicine for treating cancer, in particular, breast cancer, prostate cancer, lung cancer, multiple myeloma, leukemia, stomach cancer, ovarian cancer, colon cancer, liver cancer, pancreatic cancer and human glioma.
10 cl, 3 dwg, 8 tbl, 31 ex
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