COMPOSITION FOR TREATING OR PREVENTING ALLERGY OR ALLERGIC REACTION Russian patent published in 2024 - IPC A61K35/15 A61K35/17 A61P37/08 C12N5/78 

FIELD: medicine.

SUBSTANCE: group of inventions relates to medicine, namely to the use of a supernatant of a peripheral blood mononuclear cell (PBMC) culture for treating or preventing an allergy or an allergic reaction and a method for determining the suitability of a PBMC cell culture supernatant. Use of the PBMC cell culture supernatant for the treatment or prevention of an allergy or an allergic reaction caused by the introduction of at least one food and/or inhalation allergen or the systemic introduction of at least one drug into the human or mammal body, where the PCBMC cell culture contains 1 × 10⁵ to 1 × 10⁸ PBMC/ml, and the PBMC is exposed to ionizing radiation in dose of 10 to 60 Gy before or during cultivation. Method of determining suitability of PBMC cell culture supernatant for use in treatment or prevention of allergy or allergic reactions caused by introduction of at least one food and/or an inhalation allergen or systemic introduction of at least one drug into a human or mammal body, involving the following stages: a) bringing at least two areas of mammal skin into contact with allergen, b) introducing a PBMC cell culture supernatant into at least one of said skin areas, where at least one of said skin areas is not treated with said supernatant, c) comparing the skin areas brought into contact with the allergen with the skin areas brought into contact with the allergen and said supernatant, d) identifying differences between said areas and e) determining whether the supernatant is suitable for treating or preventing said allergy or allergic reaction, wherein the PBMC cell culture contains 1 × 10⁵ to 1 × 10⁸ PBMC/ml and PBMC are exposed to ionizing radiation in dose of 10 to 60 Gy before or during cultivation.

EFFECT: above-described group of inventions allows to prevent allergy caused by food, inhalation allergen or drug.

9 cl, 2 dwg, 2 ex