FIELD: chemistry.
SUBSTANCE: invention relates to novel biologically active derivatives of substituted 2,3-dihydrofuran-3-ones of formula I
,
where R1 represents substitutes of the type 
, where A is a condensed C6-aryl or 5-6-membered heteroaryl containing from 1 to 3 heteroatoms independently selected from N, S or O, substituted with 1 to 3 substitutes independently selected from -F, Cl, NH2, CF3, C1-C3-alkyl, C3-cycloalkyl, CN, OH, O-Rz, SO2-Rz, wherein the asterisk indicates the attachment point of the substitute; X is N or a substituent of the type CR4, where R4 is selected independently and is H, Br, CN, C2-C4-alkenyl, 5-membered heteroaryl containing 2 heteroatoms selected from N and O, C6-aryl with substitutes Cl, C3-cycloalkyl or 4-membered heterocycle containing 1 heteroatom N, R2 and R3 are independently selected and represent -C1-C6-alkyl, which can be substituted O-Rz; C2-C6-alkenyl, C6-aryl, which can be substituted with one, two or three substituents selected from F, Cl, CF3, Cl-alkyl, O-Rz, O-R2; C3-C9-cycloalkyl, or R2 and R3 together with the atom to which they are attached form 10-membered spirocycle; each Rz is independently selected and represents -H; -C1-C6-alkyl, 5-member heteroaryl containing 2 heteroatoms selected from N, 6-member heterocycle containing from 2 heteroatoms selected from N and O, tetrahydropyranyl, excluding 2-(1H-indol-2-yl)-5,5-dimethyl-4-oxo-4,5-dihydrofuran-3-carbonitrile, as well as to a pharmaceutical composition, a method for preventing a viral disease, where the virus refers to RNA viruses, use of compounds for production of medicinal agent and a drug having antiviral activity, where the virus refers to RNA viruses.
EFFECT: development and production of new chemical compounds with high efficiency for treatment of diseases caused by RNA viruses.
22 cl, 1 tbl, 9 ex
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