FIELD: medicine, pharmaceutics.
SUBSTANCE: invention described the macrocyclic compounds of formula 
wherein the radical values are presented in the patent claim. The above compounds are serine protease inhibitors wherein serine protease is hepatitis C virus (HCV) NS3 protease. This invention also discloses pharmaceutical compositions having antiviral activity against HCV, containing the claimed compounds, and one or more pharmaceutically acceptable carriers, as well as a method for preparing these compositions. The present invention describes a method of inhibiting the hepatitis C virus replication in a host, and a method of inhibiting activity of hepatitis C virus serine protease.
EFFECT: there are also presented a method of treating or preventing HCV infection, and a method of treating, preventing or ameliorating one or more symptoms of a liver disease or disorder associated with HCV infection in an individual.
69 cl, 39 ex, 8 tbl, 4 dwg
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