FIELD: medicine; pharmaceutics.
SUBSTANCE: invention relates to use of 10-(4-phenyl-5-cyano-1H-1,2,3-triazol-1-yl)pyrido[1,2-a]indole as an anticancer agent in concentration of 16 mcM, which is toxic for neoplastic cells and safe for normal human cells in vitro.
EFFECT: invention enables to use compounds of the pyrido[1,2-a]indole class as an anticancer agent and can be used in research and medical laboratories to inhibit tumor cells, particularly glioblastoma cells, in vitro.
1 cl, 6 dwg, 3 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| CHEMICAL SENSOR FOR THE DETERMINATION OF NITROAROMATIC EXPLOSIVES (EM): 10-(4,5-DI-p-TOLYL-1H-1,2,3-TRIAZOL-1-YL)-2,3-DIMETHOXY-PYRIDO[1,2-a]INDOLE | 2020 |
|
RU2756790C1 |
| BROMINE-CONTAINING STERICALLY HINDERED PHENOLS WITH ANTICANCER ACTIVITY | 2023 |
|
RU2822270C1 |
| ANTI-TUMOUR AGENT AGAINST LUNG TUMOUR | 2021 |
|
RU2765472C1 |
| 1,1'-(HEXANE-1,6-DIYL)BIS(3-(((1R,4AS,10AR)-7-ISOPROPYL-1,4A-DIMETHYL-1,2,3,4,4A,9,10,10A-OCTAHYDROPHENANTAREN-1-YL)METHYL)UREA, WHICH EXHIBITS INHIBITING ACTION ON HUMAN TYROSYL-DNA-PHOSPHODIESTERASE 1 ENZYME AND INCREASES TEMOZOLOMIDE ACTIVITY ON GLIOBLASTOMA CELLS | 2019 |
|
RU2724882C1 |
| 1-ADAMANTYL-3-(((1R,4AS,10AR)-7-ISOPROPYL-1,4A-DIMETHYL-1,2,3,4,4A,9,10,10A-OCTAHYDROPHENANTHREN-1-YL)METHYL)UREA, WHICH EXHIBITS INHIBITING ACTION ON HUMAN TYROSYL-DNA-PHOSPHODIESTERASE 1 ENZYME AND INCREASES ACTIVITY OF TEMOZOLOMIDE AGAINST GLIOBLASTOMA CELLS | 2019 |
|
RU2697409C1 |
| ((3Β-ACETOXY-URS-12-EN-28-OYL-OXYACETOXY)METHYL)-1H-1,2,3-TRIAZOL-1-YL)METHYL)-4-METHYL-1,2,5-OXADIAZOL-2-OXIDE, HAVING SELECTIVE ANTICANCER ACTIVITY AGAINST MCF-7 BREAST CANCER CELLS | 2020 |
|
RU2739559C1 |
| APPLICATION OF 2-(PYRENE-1-YL)NAPHTHO[1,2-D]OXAZOLYL-5-SULFIC ACID AS A MONOMOLECULAR AGENT FOR PHOTODYNAMIC THERAPY | 2022 |
|
RU2795221C1 |
| NEW STERICALLY HINDERED PHENOLS CONTAINING BENZOFUROXAN FRAGMENTS WITH ANTITUMOR ACTIVITY | 2022 |
|
RU2796810C1 |
| CAFFEIC ACID BIOLOGICALLY AVAILABLE FOR ORAL USE, ASSOCIATED WITH ANTITUMOUR MEDICINAL AGENTS | 2007 |
|
RU2456265C2 |
| ONCOGENIC RAS-SPECIFIC CYTOTOXIC COMPOUND AND METHODS FOR USING IT | 2006 |
|
RU2448703C2 |
