FIELD: chemistry.
SUBSTANCE: invention relates to use of 1,1'-(hexane-1,6-diyl)bis(3-(((1R,4aS,10aR)-7-isopropyl-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthren-1-yl)methyl)urea of formula I as enzyme inhibitor of human tyrosyl-DNA-phosphodiesterase 1, developing synergetic effect with temozolomide against glioblastoma cells.
I
EFFECT: what is presented is the use of a dehydroabietylamine derivative of formula I as human tyrosyl-DNA-phosphodiesterase 1 enzyme inhibitor, having high activity and low toxicity and enhancing efficacy of temozolomide action on glioblastoma cells.
1 cl, 1 dwg, 2 tbl, 3 ex
| Title | Year | Author | Number |
|---|---|---|---|
| 1-ADAMANTYL-3-(((1R,4AS,10AR)-7-ISOPROPYL-1,4A-DIMETHYL-1,2,3,4,4A,9,10,10A-OCTAHYDROPHENANTHREN-1-YL)METHYL)UREA, WHICH EXHIBITS INHIBITING ACTION ON HUMAN TYROSYL-DNA-PHOSPHODIESTERASE 1 ENZYME AND INCREASES ACTIVITY OF TEMOZOLOMIDE AGAINST GLIOBLASTOMA CELLS | 2019 |
|
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|
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