1-ADAMANTYL-3-(((1R,4AS,10AR)-7-ISOPROPYL-1,4A-DIMETHYL-1,2,3,4,4A,9,10,10A-OCTAHYDROPHENANTHREN-1-YL)METHYL)UREA, WHICH EXHIBITS INHIBITING ACTION ON HUMAN TYROSYL-DNA-PHOSPHODIESTERASE 1 ENZYME AND INCREASES ACTIVITY OF TEMOZOLOMIDE AGAINST GLIOBLASTOMA CELLS Russian patent published in 2019 - IPC C07C275/22 C07C275/24 A61K31/17 A61P35/00 

Abstract RU 2697409 C1

FIELD: chemistry.

SUBSTANCE: invention relates to organic chemistry and specifically to a compound which is 1-adamantyl-3-(((1R,4aS,10aR)-7-isopropyl-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthren-1-yl)methyl)urea of formula I.

.

EFFECT: obtaining a new adamantane derivative having the ability to inhibit human tyrosyl-DNA-phosphodiesterase 1 (Tdp1) enzyme.

1 cl, 1 dwg, 2 tbl, 3 ex

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RU 2 697 409 C1

Authors

Oleshko Olga Sergeevna

Kovaleva Kseniya Sergeevna

Yarovaya Olga Ivanovna

Mamontova Evgeniya Mikhajlovna

Zakharenko Aleksandra Leonidovna

Zakharova Olga Dmitrievna

Cheresiz Sergej Vladimirovich

Pokrovskij Andrej Georgievich

Lavrik Olga Ivanovna

Salakhutdinov Nariman Faridovich

Dates

2019-08-14Published

2019-04-30Filed