METHOD FOR DIAGNOSING PATHOLOGY OF MEDIASTINAL LYMPH NODES AND LUNG PARENCHYMA Russian patent published in 2024 - IPC A61B8/08 A61K49/22 A61P43/00 

FIELD: medicine.

SUBSTANCE: invention relates to endoscopy and pulmonary oncology, and can be used for diagnosing pathology of mediastinum and lung. Ultrasound scanning of selected target in mediastinum or lung parenchyma is performed by transbronchial or transesophageal approach in B-mode with the determination of the pathological growth area with the evaluation of its ultrasonic parameters, including the dimensions, as well as in the color Doppler mapping mode with determining the degree of vascularization of the pathological formation and selecting the area of interest for performing the targeted biopsy and in a sonoelastography mode with a non-invasive assessment of the density of the pathological formation to clarify the area of interest in the subsequent targeted biopsy. Intravenous bolus introduction of contrast agent is performed, at the same time, before the introduction of the contrast preparation, the contrast enhancement mode is set with the mechanical index M1=0.1 at the beginning of the introduction of the bolus of the contrast agent, a timer mode is started with control of the dynamics of the accumulation of the contrast agent, tracking is carried out for 180 seconds, rate of contrast accumulation in arterial phase and parenchymal phase is assessed, as well as assessing the contrast agent accumulation patterns in the pathological formation structure with their fixation and performing targeted biopsy of areas with disturbed architectonics of vasculature according to accumulation of contrast agent, wherein the homogeneous distribution of the contrast in the structure of the pathological formation is referred to as a benign process; heterogeneous contrast distribution in the structure of the pathological formation is referred to as a malignant process; absence of contrast accumulation in the structure of the pathological growth is referred to as an uncertain diagnostic result.

EFFECT: method enables to detect hidden features of microvascularization of the target, as well as to select zones of pathological changes in the structure of the mediastinal lymph node or lung formation with high accuracy, due to the proposed modes of contrast ultrasonic amplification.

2 cl, 3 dwg, 3 ex