FIELD: medicine; chemistry; pharmaceutics.
SUBSTANCE: group of inventions relates to chemistry and pharmaceutics, specifically to immobilized on hyaluronic acid gel bis(L-threoninate) germanium (IV) dihydroxide with chemical formula [Ge(Thr)2(OH)2], having prolonged action antimicrobial activity, and to method of its production. Proposed method is characterized by the following steps: for preparing the gel, hyaluronic acid is mixed with distilled water in a weight ratio of (0.5-10)/100, respectively, for 30-40 minutes at room temperature; settling the obtained gel base for 12 hours and re-stirring for 30-40 minutes; then, while stirring, bis(L-threoninate) germanium (IV) dihydroxide is added to the obtained gel base in a weight ratio greater than or equal to 1/100, respectively.
EFFECT: group of inventions provides a synergistic antimicrobial effect.
2 cl, 2 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| HEMIN DERIVATIVES, HAVING ANTIMICROBIAL ACTIVITY OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, SYNTHESIS METHOD, PHARMACEUTICAL COMPOSITION AND USE | 2009 |
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|
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| NOVEL HEMIN DERIVATIVES HAVING ANTIBACTERIAL AND ANTIVIRAL ACTIVITY | 2011 |
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| METHOD FOR PRODUCING IMMOBILIZED ENZYME PREPARATION BASED ON BROMELAIN, HYALURONIC ACID AND POLYSACCHARIDES MODIFIED WITH VINYL MONOMERS | 2020 |
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| METHOD OF PRODUCING HYBRID PREPARATION OF FICIN AND CHITOSAN ASCORBATE IN FORM OF THICK SOLUTION | 2023 |
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| METHOD FOR PRODUCING IMMOBILIZED ENZYME PREPARATION BASED ON COLLAGENASE, HYALURONIC ACID AND POLYSACCHARIDES MODIFIED WITH VINYL MONOMERS | 2020 |
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