FIELD: chemistry; medicine.
SUBSTANCE: invention relates to 1-(6-(methoxy)pyridazin-3-yl)-cyclopropane-1-carboxamide derivatives of formula (I), where A, E, K are defined in the claim, as autotaxin (ATX) modulators.
EFFECT: invention can be used to treat inflammatory diseases of the respiratory tract or fibrotic diseases, such as, for example, idiopathic pulmonary fibrosis (IPF) or systemic sclerosis (SSc).
21 cl, 9 tbl, 31 ex
| Title | Year | Author | Number |
|---|---|---|---|
| DERIVATIVE OF PYRROLOPYRIMIDINE AND APPLICATION THEREOF | 2020 |
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| PYRIMIDINE COMPOUND AND METHOD FOR ITS PRODUCTION | 2020 |
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| NEW DERIVATIVES OF 3,5-DISUBSTITUTED PYRIDINE AND 3,5-DISUBSTITUTED PYRIDAZINE AND THEIR PHARMACEUTICAL USE | 2019 |
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| ASK1-INHIBITING PYRROLOPYRIMIDINE AND PYRROLOPYRIDINE DERIVATIVES | 2018 |
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| 3-ARYL-5-SUBSTITUTED ISOQUINOLIN-1-ONE COMPOUNDS AND THEIR THERAPEUTIC APPLICATION | 2013 |
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RU2696572C2 |
| PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING FIBROSIS | 2022 |
|
RU2829908C2 |
| NEW BICYCLIC COMPOUNDS AS DOUBLE INHIBITORS OF AUTOTAXIN (ATX)/CARBONIC ANHYDRASE (CA) | 2016 |
|
RU2725138C2 |
| NOVEL SPIRO[IMIDAZOLIDINE-4,3'-INDOLE]-2,2',5(1'H)-TRIONES FOR TREATING CONDITIONS ASSOCIATED WITH VANILLOID RECEPTOR 1 | 2007 |
|
RU2421457C2 |
| 1-((3S,4R)-4-(3-FLUOROPHENYL)-1-(2-METHOXYETHYL)PYRROLIDIN-3-YL)-3-(4-METHYL-3-(2-METHYLPYRIMIDIN-5-YL)-1-PHENYL-1N-PYRAZOL-5-YL)UREA AS A TRKA KINASE INHIBITOR | 2015 |
|
RU2719489C2 |
| 1-(2-ISOPROPOXYETHYL)-2-THIOXO-1,2,3,5-TETRAHYDRO-PYRROLO[3,2-d]PYRIMIDIN-4-ONE AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF | 2005 |
|
RU2409578C2 |
