FIELD: chemistry.
SUBSTANCE: invention relates to a compound (4R)-1'-[(2E)-3-(3,4-dichlorophenyl)prop-2-en-1-yl]-2H,5H-spiro[imidazolidine-4,3'-indole]-2,2',5(1'H)-trione or pharmaceutically acceptable salt thereof. The invention also relates to use of the said compound to prepare a medicinal agent for use in therapy of conditions associated with vanilloid receptor 1 (VR1).
EFFECT: novel optical isomer which can be used to treat acute or chronic disorders.
6 cl, 2 tbl
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| DERIVATIVES OF 2,5-DIOXOIMIDAZOLIDINE-1-YL-3-PHENYLUREA AS MODULATORS OF FORMYLPEEPTITIDE RECEPTOR 1 (FPRL-1) | 2012 |
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RU2645673C2 |
| COMPOUNDS 6,7-DIHYDRO-5H-PYRAZOLO[5,1-B][1,3]OXAZINE-2-CARBOXAMIDE | 2017 |
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RU2719599C2 |
| SPIROCYCLIC CYCLOHEXANE DERIVATIVES | 2008 |
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| PYRROLOINDOLES, PYRIDINEINDOLES AND AZEPINOINDOLES AS 5-HT AGONISTS | 1999 |
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RU2232162C2 |
| BENZIMIDAZOLE DERIVATIVES IN TREATING DISORDERS ASSOCIATED WITH VANILLOID RECEPTOR TRPV1 | 2007 |
|
RU2458055C2 |
| NICOTINIC RECEPTOR LIGANDS | 2007 |
|
RU2441007C2 |
| 1-(2-ISOPROPOXYETHYL)-2-THIOXO-1,2,3,5-TETRAHYDRO-PYRROLO[3,2-d]PYRIMIDIN-4-ONE AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF | 2005 |
|
RU2409578C2 |
| BICYCLIC PIPERAZINE COMPOUNDS | 2012 |
|
RU2628616C2 |
| NEW 3-INDOLE SUBSTITUTED DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND METHODS OF APPLICATION | 2016 |
|
RU2672252C1 |
| SERINE/THREONINE KINASE INHIBITORS | 2013 |
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RU2650501C2 |
