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(19)

(11)

2 742 333

(13)

(51)

IPC

C07J9/00(2006-01-01)

C07J17/00(2006-01-01)

A61K31/575(2006-01-01)

A61K31/58(2006-01-01)

A61P1/04(2006-01-01)

A61P3/10(2006-01-01)

A61P25/00(2006-01-01)

A61P25/20(2006-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2018104245, 2016-07-06

(24)

Start date

2016-07-06

(22)

Actual filing date

2016-07-06

(45)

Published

2021-02-04

(72)

Inventor

Salituro, Francesco, G.Robichaud, Albert, JeanMartinez Botella, GabrielHarrison, Boyd, L.

(73)

Holder

Sage Therapeutics, Inc.

OXYSTEROLES AND METHODS OF USING THEM Russian patent published in 2021 - IPC C07J9/00 C07J17/00 A61K31/575 A61K31/58 A61P1/04 A61P3/10 A61P25/00 A61P25/20 A61P35/00

Abstract RU 2742333 C2

FIELD: pharmaceuticals.

SUBSTANCE: invention relates to a compound of formula (I-C-i) or pharmaceutically acceptable salts thereof. In formula (I-C-i), R¹ is C_1-6 alkyl and R² is -CH₂CF₃,ethyl, isopropyl or cyclopropyl. Invention also relates to a pharmaceutical composition and a method for positive allosteric modulation of the NMDA receptor.

EFFECT: obtaining novel compounds of formula (I-C-i), which have the property of a positive allosteric NMDA modulator and can be used in treating NMDA-mediated disorders.

17 cl, 1 tbl, 39 ex

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RU 2 742 333 C2

Authors

Salituro, Francesco, G.

Robichaud, Albert, Jean

Martinez Botella, Gabriel

Harrison, Boyd, L.

Dates

2021-02-04—Published

2016-07-06—Filed