FIELD: medicine.
SUBSTANCE: invention relates to clinical oncology, medical genetics and molecular diagnostics, and can be used to predict the risk of triple negative breast cancer in women. DNA is recovered from peripheral venous blood. Analysis of genetic markers rs8023580 of the NR2F2 gene, rs440837 of the ZBTB10 gene, rs17496332 of the PRMT6 gene. When detecting a combination of genotypes rs8023580TT of the NR2F2 gene—rs440837AA of the ZBTB10 gene—rs17496332GG of the PRMT6 gene, high risk of developing triple negative breast cancer is predicted.
EFFECT: method provides obtaining new criteria for assessing the risk of developing triple negative breast cancer in women of Russian nationality, natives of the Central Black Earth Region of the Russian Federation, based on data on polymorphic markers rs8023580 NR2F2—rs440837 ZBTB10—rs17496332 PRMT6.
1 cl, 3 dwg, 4 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD FOR PREDICTION OF INCREASED RISK OF DEVELOPING BREAST CANCER OF 3-4 STAGES OF DISEASE IN WOMEN | 2024 |
|
RU2830466C1 |
| METHOD FOR PREDICTION OF RISK OF DEVELOPING BREAST CANCER IN WOMEN WITHOUT OBESITY BY RESULTS OF GENETIC TESTING | 2024 |
|
RU2828525C1 |
| METHOD FOR PREDICTION OF RISK OF DEVELOPING BREAST CANCER IN WOMEN BASED ON DATA ON INTERLOCUS INTERACTIONS | 2023 |
|
RU2815932C1 |
| METHOD FOR PREDICTING RISK OF GRADE 3 MALIGNANCY OF TUMOR CELLS IN BREAST CANCER | 2024 |
|
RU2830352C1 |
| METHOD FOR PREDICTION OF RISK OF DEVELOPING LUMINAL SUBTYPE OF BREAST CANCER IN WOMEN | 2024 |
|
RU2828523C1 |
| METHOD FOR PREDICTION OF RISK OF DEVELOPING BREAST CANCER IN WOMEN WITH OBESITY BASED ON DATA ON POLYMORPHISM OF GENES JMJD1C, PPP1R21 AND PRMT6 | 2024 |
|
RU2830467C1 |
| METHOD OF PREDICTING RISK OF DEVELOPING TRIPLE-NEGATIVE BREAST CANCER | 2023 |
|
RU2811257C1 |
| METHOD FOR PREDICTING THE RISK OF DEVELOPMENT OF THE LUMINAL SUBTYPE OF BREAST CANCER | 2023 |
|
RU2795720C1 |
| METHOD OF PREDICTING A LOW RISK OF DEVELOPING BREAST CANCER IN WOMEN WITH HIGHLY PENETRATING MUTATIONS IN THE BRCA1 AND CHEK2 GENES | 2022 |
|
RU2798666C1 |
| METHOD FOR PREDICTION OF BREAST CANCER RISK DEVELOPMENT IN NON-OBESE WOMEN | 2023 |
|
RU2795726C1 |
