FIELD: medicine.
SUBSTANCE: invention relates to clinical oncology, medical genetics and molecular diagnostics, and can be used to predict the risk of developing grade 3 malignant cells in breast cancer in Russian women who are natives of the Central Black Earth Region of the Russian Federation. DNA is recovered from peripheral venous blood. Analysis of polymorphic markers rs7910927 of the JMJD1C gene, rs440837 of the ZBTB10 gene and rs10454142 of the PPP1R21 gene. When detecting a combination of genotypes rs7910927-GG of the JMJD1C gene—rs440837-AG of the ZBTB10 gene—rs10454142-CC of the PPP1R21 gene high risk of developing grade 3 malignant cells in breast cancer is predicted.
EFFECT: method provides obtaining new criteria for assessing an increased risk of developing grade 3 malignant cells in breast cancer in women of Russian nationality, natives of the Central Black Earth Region of the Russian Federation, based on data on polymorphic markers rs7910927 JMJD1C—rs440837 ZBTB10—rs10454142 PPP1R21.
1 cl, 3 dwg, 5 ex
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