FIELD: medicine.
SUBSTANCE: invention relates to clinical oncology, medical genetics and molecular diagnostics, and can be used to predict the risk of developing grade 3 malignant cells in breast cancer. DNA is recovered from peripheral venous blood. Genetic markers of the MMP-9 gene are analyzed. When detecting haplotype CTAACG polymorphic loci rs3918242-rs3918249-rs17576-rs3787268-rs2250889-rs17577 of the MMP-9 gene high risk of developing grade 3 malignant cells in breast cancer is predicted.
EFFECT: method provides obtaining new criteria for assessing the risk of developing grade 3 tumor cells in breast cancer in Russian women, natives of the Central Black Earth Region of the Russian Federation, based on polymorphic loci data rs3918242-rs3918249-rs17576-rs3787268-rs2250889-rs17577 of the MMP-9 gene.
1 cl, 6 dwg, 4 ex
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