FIELD: organic chemistry. SUBSTANCE: product: derivatives of azetidinone of the formula (I) where R1 hydroxy-protective group; R2 - C1-C3-alkyl; R3 nonsubstituted pyridyl or pyridyl substituted with C1-C3-alkyl, nonsubstituted quinolyl, phenyl substituted with C1-C3-alkyl or CYNR5-R6,-group where Y oxygen or sulfur, and R5 and R6 are similar or different and mean C1-C6-alkyl or phenyl, or R5 and R6 together form pyrrolidinyl, piperidyl, morpholinyl or azepinyl; R4 hydrogen; Z sulfur or oxygen atom. Reagent 1: compound of the formula (II) where R2, R3 and Z as indicated above; R7,, R8 and R9 are similar or different and mean C1-C4-alkyl or phenyl. Reagent 2: compound of the formula (III) where R1 and R4 as indicated above; R10 - acyloxy-, alkylsulfonyl-, arylsulfonyl-, alkylsulfinyl- or arylsulfinyl-group. Synthesized compounds were used as intermediate products for synthesis carbapenem antibiotics. EFFECT: improved method of synthesis. 5 cl
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Authors
Dates
1995-11-10—Published
1992-05-29—Filed