FIELD: medicine.
SUBSTANCE: what is presented is a method for prediction of the population biotransformation disorders of foreign substances caused by the exposure to man-induced chemical habitat factors. One ethnic population living on the territory of the exposure to hazardous chemical factors is sampled; buccal epithelium is sampled; DNA is recovered that is followed by genotyping of the polymorphous version 9893A/G of CYP1A1 gene, 921A/C of CPOX gene, and G308A of TNF-alpha gene; one of the following gene conditions are stated: heterozygous, normal homozygous or minor homozygous; a prevalence ratio of the minor alleles for the genes studied is calculated by formula; and the population disorders are predicted.
EFFECT: invention enables the accurate and reliable prediction of the population biotransformation disorders of foreign substances caused by the exposure to man-induced chemical habitat factors and may be used for providing the preventive ways to protect and stabilise an ethnic population genome in conditions of the increasing environmental pollution.
2 tbl, 1 ex
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