METHOD OF MAKING DERMAL FILLER AND PREPARING THEREOF FOR USE Russian patent published in 2025 - IPC A61L27/12 A61L27/20 

FIELD: medicine.

SUBSTANCE: group of inventions relates to aesthetic medicine and concerns the manufacture and preparation for use of a dermal filler intended for volume and linear smoothing of face and body skin and correction of skin defects. Method of producing dermal filler involves synthesis of monophasic hydroxyapatite Ca₁₀(PO₄)₆(OH)₂ from aqueous solutions of calcium chloride, dibasic ammonium phosphate and ammonia in the following ratios, wt.%: calcium chloride - 50.83, disubstituted ammonium phosphate - 36.33, ammonia - 12.84, with precipitation until establishment. pH = (5.5–9.5) ± 0.5 units 10CaCl₂ + 6(NH₄)2HPO₄ + 8NH₄OH = Ca₁₀(PO₄)₆(OH)₂ + 20NH₄Cl + 6H₂O, after which the suspension of freshly precipitated hydroxyapatite is filtered and washed with water, dried at temperature from 90 to 100°C and calcined at 750–800 °C. Powder of hydroxyapatite is cooled in annealing furnace, classified, fraction of 10–50 mcm is separated, which is distributed in deionised water with addition of glycerine and sodium salt of carboxyl cellulose in the following ratios, wt.%: deionised water - 76.0, monophasic hydroxyapatite Ca₁₀(PO₄)₆(OH)₂ - 15.2, glycerine - 7.6, sodium carboxymethyl cellulose - 1.2. Method provides producing the filler with high efficiency of application, long duration of preservation of therapeutic dermal effect and elimination of possibility of side effects. Method for preparation for use of a dermal filler made using said method, consists in the fact that the dermal filler is diluted in the patient’s blood plasma at ratio of 1:1 or the filler is diluted in the patient’s blood plasma with the addition of lidocaine at ratio of 0.4:1:0.2 or at ratio of 0.6:1:0.2.

EFFECT: use of the group of inventions provides a wider range of technical means which can be used to make dermal fillers.

2 cl, 2 dwg, 3 ex