FIELD: biotechnology.
SUBSTANCE: invention relates to biotechnology and represents a version of beta-carotene-15,15'-oxygenase, where the amino acid corresponding to position 43 relative to the N-terminal of the amino acid sequence SEQ ID NO: 1, alanine; amino acid corresponding to position 58 relative to the N-terminal of the amino acid sequence SEQ ID NO: 1, leucine; and an amino acid corresponding to position 74 relative to the N-terminal of the amino acid sequence SEQ ID NO: 1, isoleucine, each replaced with another amino acid, where the variant has beta-carotene-15,15'-oxygenase activity, as well as a microorganism containing a polynucleotide coding the beta-carotene-15,15'-oxygenase variant.
EFFECT: invention enables to obtain a retinoid by culturing such a microorganism with a high degree of efficiency.
15 cl, 4 tbl, 4 ex
| Title | Year | Author | Number |
|---|---|---|---|
| LYSE VARIANT AND METHOD FOR PRODUCING L-ARGININE USING SAME | 2022 |
|
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| MICROORGANISM HAVING DNA-BINDING TRANSCRIPTION REGULATOR OF LACI FAMILY WITH WEAKENED ACTIVITY, AND METHOD FOR PRODUCING L-GLUTAMIC ACID USING IT | 2022 |
|
RU2833333C2 |
| NOVEL VERSION OF ACETATE METABOLISM REGULATOR A AND METHOD FOR PRODUCTION OF BRANCHED CHAIN L-AMINO ACIDS USING IT | 2022 |
|
RU2838060C2 |
| MICROORGANISM OF GENUS CORYNEBACTERIUM, PRODUCING L-ARGININE, AND METHOD OF PRODUCING L-ARGININE USING SAID MICROORGANISM | 2022 |
|
RU2837670C2 |
| BCMA-SPECIFIC CHIMERIC ANTIGEN RECEPTORS CONTAINING IL-6 SIGNALLING BLOCKER | 2023 |
|
RU2828294C1 |
| ANTISENSE OLIGONUCLEOTIDES TARGETING CAV3.1 GENE AND USES THEREOF | 2022 |
|
RU2839721C2 |
| MONOCLONAL ANTIBODIES SPECIFIC TO PROTEIN RUSTICYANIN, AND USE OF ANTIBODIES FOR DIAGNOSIS AND TREATMENT OF MALIGNANT NEOPLASMS | 2024 |
|
RU2823344C1 |
| ISOLATED MODIFIED CAPSID PROTEIN VPI OF ADENO-ASSOCIATED VIRUS SEROTYPE 5 (AAV5), CAPSID AND VECTOR BASED THEREON | 2021 |
|
RU2820088C1 |
| BISPECIFIC ANTIBODIES AND THEIR APPLICATIONS | 2022 |
|
RU2821577C2 |
| NUCLEOTIDE SEQUENCE CODING LYTICASE ENZYME, AND PANEL OF OLIGONUCLEOTIDES FOR OBTAINING SYNTHETIC NUCLEOTIDE SEQUENCE OF LYTICASE GENE | 2023 |
|
RU2826150C1 |
