FIELD: chemistry.
SUBSTANCE: invention relates to organosilicon chemistry and is a method of producing 1-(3-(trimethoxysilyl)propyl)benzimidazole, used for synthesis of immobilized ionic liquids, obtaining films on metal surfaces as an intermediate product in synthesis of biologically active compounds. Method is carried out in one reactor in two steps. At the first step, a sodium salt of benzimidazole is obtained by heating equimolar amounts of benzimidazole and sodium hydroxide in a toluene medium with water separation. Half of the used toluene is then distilled off, dimethylformamide is added to the reaction mass and the sodium salt of benzimidazole is alkylated with (3-chloropropyl)trimethoxysilane while heating for 3 hours at the boiling point of the reaction mass.
EFFECT: improved method of producing 1-(3-(trimethoxysilyl)propyl)benzimidazole using readily available starting reagents and a solvent which provides high output of the end product.
1 cl, 1 ex
Title | Year | Author | Number |
---|---|---|---|
METHOD OF PRODUCING 1-(3-(TRIMETHOXYSILYL)PROPYL)-1H-IMIDAZOLE | 2023 |
|
RU2805918C1 |
METHOD OF PRODUCING 1- AND 2-(3-(TRIMETHOXYSILYL)PROPYL)BENZOTRIAZOLES | 2024 |
|
RU2836237C1 |
METHOD OF PRODUCING 1-(3-(TRIMETHOXYSILYL)PROPYL)-1H-1,2,4-TRIAZOLE | 2023 |
|
RU2820705C1 |
METHOD FOR FUNCTIONALIZATION OF SILICA GEL SURFACE BY ALDEHYDE GROUPS | 2020 |
|
RU2750868C1 |
METHOD OF PRODUCING CARBOXYLIC ACID AMIDES | 2014 |
|
RU2565059C1 |
METHOD OF PREPARING 1-(BENZAZOLYLALKYL)PIPERIDINE DERIVATIVES OR THEIR SALTS | 0 |
|
SU701534A3 |
DERIVATIVES OF N-(3-HYDROXY-4-PIPERIDINYL)-(DIHYDROBENZOFURAN, DIHYDRO-2H-BENZOPYRAN OR DIHYDROBENZODIOXINE)-CARBOXAMIDE AND PHARMACEUTICAL COMPOSITION | 1993 |
|
RU2108332C1 |
METHOD OF PRODUCING SILICAGEL WITH IMMOBILIZED TETRAZOLIUM SALT | 2018 |
|
RU2696390C1 |
HYDROCHLORIDES OF 1-ALKYL-3-METHYL-8-PIPERAZINO-7-(TIETHANYL-3)XANTHINE SHOWING ANTITHROMBOTIC EFFECT BY BLOCKING GP IIb-IIIa PLATELETS RECEPTORS | 2017 |
|
RU2640579C1 |
METHOD OF SYNTHESIS OF DERIVATIVES OF N-(3-HYDROXY-4-PIPERIDINYL)-(DIHYDROBENZOFURAN, DIHYDRO-2H-BENZOPYRAN OR DIHYDROBENZODIOXINE)-CARBOXAMIDE, OR THEIR SALTS, OR THEIR STEREOCHEMICALLY ISOMERIC FORM | 1990 |
|
RU2037492C1 |
Authors
Dates
2025-01-28—Published
2024-06-14—Filed