METHOD FOR IN VITRO FERTILIZATION (IVF) IN NATURAL CYCLE IN ABSENCE OF HYPERPROLACTINEMIA Russian patent published in 2025 - IPC A61B17/425 A61K31/48 A61P15/08 A61B8/12 G01N33/74 

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to obstetrics and gynaecology, reproductology and assisted reproductive technologies, and can be used in in vitro fertilization in a natural cycle in the absence of hyperprolactinemia. On 2nd day of the menstrual cycle (MC), the presence and diameter of antral follicles, the level of follicle-stimulating hormone (FSH) in blood serum are determined during an ultrasound examination. If there is at least one antral follicle with a diameter of at least 5 mm and the FSH level is more than 10 mIU/ml, the antral follicle with the largest diameter is determined as a dominant one. Then, on 5th day of the MC, the diameter of the dominant follicle is determined; if its diameter has increased by less than 6 mm, the patient with a body weight index (BWI) more than 25 takes 0.25 mg of cabergoline, and with a BWI less than or equal to 25 – 0.125 mg of cabergoline. Then, 3 days after the administration of cabergoline, the diameter of the dominant follicle is determined, and if its diameter has increased by less than 6 mm, then the patient with BWI more than 25 takes 0.25 mg of cabergoline, and with BWI less than or equal to 25 – 0.125 mg of cabergoline. After 3 days, the diameter of the dominant follicle is determined, and if its diameter is 16-20 mm, a transvaginal puncture of the dominant follicle is performed; oocyte insemination or intracytoplasmic sperm injection and embryo transfer into uterine cavity.

EFFECT: method provides the possibility of obtaining eggs with slowing down or absence of follicle growth during the follicular phase, reducing the frequency of cancellation of IVF cycles, increased probability of obtaining own oocytes in patients with poor ovarian reserve with minimal hormonal modification of natural cycle due to levelling of functional excess production of prolactin.

1 cl, 2 ex