METHOD FOR PREPARING ENTERIC ORAL FORM OF 5-FLUOROURACIL Russian patent published in 2025 - IPC A61K31/505 A61K9/50 

FIELD: chemistry.

SUBSTANCE: present invention relates to a method of producing an enteric oral form of 5-fluorouracil, characterized by that 1% of sodium alginate solution is mixed with 5-fluorouracil as a suspension in ratio of 13:1 and stabilized with polysorbate-80; mixture is added in drops to 10% of aqueous solution of calcium chloride with addition of 0.2% of polysorbate-80; obtained microcapsules are filtered, dried in a dry-heat oven at temperature of 60 °C to constant weight, milled and mixed with filler, which is sucrose-starch in ratio of 1:2; obtained powder mixture is granulated in presence of 30% of aqueous dispersion of a copolymer of methacrylic acid and ethyl acrylate 1:1, containing 1% of polyvinylpyrrolidone, 0.7% sodium lauryl sulphate and 2.3% of polysorbate-80 as emulsifiers, rubbed through a sieve, dried to constant weight and coated with composition of 15% aqueous dispersion of a copolymer of methacrylic acid and ethyl acrylate 1:1, containing 0.35% sodium lauryl sulphate and 1.15% polysorbate-80 as emulsifiers.

EFFECT: present invention provides an oral form of 5-fluorouracil (granulate), which is enteric.

1 cl, 3 dwg