METHOD FOR DETERMINING THE RISK OF DEVELOPING ACUTE MYOCARDIAL INFARCTION IN PATIENTS WITH ESSENTIAL ARTERIAL HYPERTENSION FOR 18 MONTHS AFTER A NEW CORONAVIRUS INFECTION (COVID-19) Russian patent published in 2025 - IPC G01N33/68 G01N33/82 

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to immunology and cardiology, and can be used to determine the risk of developing acute myocardial infarction in patients with essential arterial hypertension for 18 months after suffering a new coronavirus infection (COVID-19). Levels of soluble receptor of interleukin 6 (sIL6r) factor in blood at 08:00 and 20:00 and 25 (OH)D at 08:00 of one day, in pg/ml and ng/ml respectively. Blood sampling day is selected from 10th to 30th day after the first negative result of SARS-CoV-2 RNA PCR. A coefficient reflecting the ratio of sIL6r at 20:00 to sIL6r at 08:00 in percent is calculated. If at 08:00 the patient’s blood serum sIL6r level is 2500 pg/ml or more with a subsequent increase in sIL6r levels at 20:00 by 60 % or more and a blood serum level of 25 (OH)D 30 ng/ml or less, a high risk is determined. If at 08:00 the patient’s blood serum sIL6r level is 2500 pg/ml or more with a subsequent increase in sIL6r levels at 20:00 by 60 % or more and a blood serum level of 25 (OH)D more than 30 ng/ml, an average risk is determined. If at 08:00 the sIL6r level is 2500 pg/ml and more with a subsequent increase in the sIL6r level at 20:00 to 60 % regardless of level of 25 (OH)D, the average risk is also determined. If 08:00 the patient’s blood serum sIL6r level is less than 2500 pg/ml irrespective of the sIL6r dynamics at 20:00 and level of 25 (OH)D, a low risk is determined.

EFFECT: method provides the possibility of increasing the accuracy of calculating the individual risk of developing lethal and non-lethal myocardial infarction in patients with essential arterial hypertension for 18 months after suffering COVID-19 by studying the level of sIL-6r in blood serum at 08:00 and 20:00, as well as 25 (OH)D at 8:00 of one day during the period of early recovery after a new coronavirus infection.

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